ABSTRACT
Objective::To observe the clinical efficacy of dialectical therapy of Bufeitang combined with Shengesan and Fujiu application on chronic obstructive pulmonary disease (COPD) and lung-kidney Qi deficiency syndrome, and its effect on inflammatory damage and airway remodeling. Method::One hundred and thirty-four patients were randomly divided into control group (66 cases) and observation group (68 cases) by random number table. Patients in control group got spiriva by powder inhaler, 1 grain/time, 1 time/day, and salmeterol xinafoate and fluticasone propionate powder for inhalation for spray as appropriate, 1 suction/time, 1-2 times/days, for a continued 12 months. In addition to the therapy of control group, patients in observation group were also given Fujiu application at two-tailed acupoints of Feiyu, Piyu and Shenyu for the first day of the every San Fu and San Jiu, and dialectical therapy of Bufeitang combined with Shengesan were given at the first day of San Fu and San Jiu for 2 months. The course of treatment was 12 months. Before and after treatment, FEV1% of self-assessment questionnaire of patients with COPD (CAT), 6-min walking distance, St George's respiratory questionnaire (SGRQ), severity of dyspnea (mMRC) and index of BODE were assessed. And levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), matrix metalloproteinase-9 (MMP-9) and matrix metalloproteinase inhibitor-1 (TIMP-1) were detected. Result::After treatment, scores of CAT, the total score of SGRQ, scoring of each dimension and index of BODE in observation group were all lower than that in control group (P<0.01), while FEV1% was higher than that in control group (P<0.01). And 6-min walking distance was more than that in control group (P<0.01), and the numbers of acute exacerbations were less than that in control group (P<0.01). The severity of dyspnea was lighter than that in control group (Z=2.047, P<0.05). And levels of MMP-9, TNF-α, IL-6 and ratio of MMP-9/TIMP-1 were lower than those in control group (P<0.01), whereas the level of TIMP-1 was higher than that in control group (P<0.01). Conclusion::Dialectical therapy of Bufei decoction combined with Shenge powder and Fujiu application can alleviate the current symptoms of dyspnea, improve exercise tolerance, quality of life and pulmonary function, reduce the number of acute exacerbations, relieve inflammation damage and airway remodeling. The comprehensive clinical efficacy is better than that of conventional western medicine.
ABSTRACT
Objective::To discuss the efficacy of compound Huangteng mixture for acute radiation enteritis (ARE) and to investigate its regulatory effect on serum inflammatory factors. Method::One hundred and forty patients were randomly divided into control group (70 cases) and observation group (70 cases) by random number table. Patients in control group got precise radiotherapy. And take montmorillorillonite powder orally based on the treatment in control group, patients in observation group additionally received compound Huangteng mixture, 1 dose/day. The treatment was continued to the second week after the ending of radiotherapy in both groups. Time of appearance of ARE (1 and 2 levels), irradiation dose and incidence of severe ARE (3 and 4 levels) were recorded. Endoscope examination was conducted at the second week after the ending of radiotherapy. ARE symptom scores and KPS scores of quality of life were graded. Levels of serum interleukin-1 (IL-1), IL-4, IL-6, tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were detected both before and after treatment. Result::Time of appearance of ARE (1 and 2 levels) in observation group was shorter than those in control group (P<0.01), and irradiation dose was more than that in control group (P<0.01). At the fourth and fifth week of radiotherapy and at the second week after the ending of radiotherapy, incidence rate of ARE (levels 2 and above) was 42.86%(30/70), 50.00%(35/70) and 54.29%(38/70), all lower than 61.43%(43/70), 68.57%(48/70) and 74.29%(52/70) in control group (χ2=4.837, P<0.05, χ2=5.001, P<0.05, χ2=6.097, P<0.05). After radiotherapy, incidence of ARE was 62.86%(44/70) in observation group, lower than 78.57%(55/70) in control group (χ2=4.173, P<0.05), and the incidence of severeARE was 13.64%(6/44) in observation group, lower than 32.73%(18/55) in control group (χ2=4.851, P<0.05). Scores of endoscope and ARE symptoms in observation group were lower than those in control group, while score of KPS was higher than that in control group (P<0.01). After radiotherapy, levels of IL-1, IL-6, TNF-α and CRP in observation group were lower than those in control group (P<0.01), while level of IL-4 was higher than that in control group (P<0.01). Conclusion::Compound Huangteng mixture combined with radiotherapy can reduce the incidence of ARE, postpone the occurrence of ARE, relieve the severity of ARE, regulate the expression of inflammatory factors, alleviate clinical symptoms, and improve the quality of life in patients withradiotherapy, thus it is conducive to the sequential development of radiotherapy.
ABSTRACT
Objective To observe the curative effect of Fuzhengxiaojia decoction on precancerous lesion of gastric cancer (PLGC).Methods We randomly divided 44 patients with PLGC in our hospital into control group (n=22)and treatment group (n=22).The control group was given 4 Weifuchun tablets each time and three times per day and while the treatment group was given one Fuzhengxiaojia decoction of 400 mL besides the medication of the control group.They were treated for two courses,one course lasting for one month.Results Superoxide dismutase (SOD),malondialdehyde (MDA),glutathione peroxidase (GSH-Px),IgG,IgM and IgA in the two groups had no significant differences before treatment (P＞0.05).After treatment,compared with those in the control group,SOD (t=2.144,P=0.044)and GSH-Px (t=2.322,P=0.030)increased,while MDA(t=3.096, P=0.005),IgG(t=2.421,P=0.025),IgM(t=3.377,P=0.003)and IgA (t=2.521,P=0.020)decreased. The main symptom scores in the two groups did not significantly differ before treatment (P＜0.05).After treatment, compared with those in the control group,the scores for main symptoms like reduced food intake (t=3.924,P＜0.001),stomach noise (t=4.161,P＜0.001)and gastric or hypochondriac swelling (t=2.881,P＜0.009) decreased in the treatment group.The rate of effective cases was higher than that in the control group (χ2=4.539, P=0.033).Conclusion The effect of Weifuchun combined with Fuzhengxiaojia prescriptions in treating PLGC is better than Weifuchun alone,which is related to improving redox and immunoglobulin.